Hiroshi Kitagawa Selected Research

Chondroitin

10/2021	Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.
1/2021	Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation.
12/2015	Involvement of chondroitin 6-sulfation in temporal lobe epilepsy.
5/2014	Chondroitin 6-O-sulfate ameliorates experimental autoimmune encephalomyelitis.
10/2013	A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1.
2/2011	Chondroitin beta-1,4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies.
12/2006	Chondroitin 4-O-sulfotransferase-1 regulates E disaccharide expression of chondroitin sulfate required for herpes simplex virus infectivity.
5/2003	Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans.

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Hiroshi Kitagawa Research Topics

Disease

16	Neoplasms (Cancer) 01/2022 - 07/2002
5	Multiple Hereditary Exostoses (Hereditary Multiple Exostoses) 03/2013 - 04/2002
4	Breast Neoplasms (Breast Cancer) 01/2022 - 05/2014
4	Hypoxia (Hypoxemia) 01/2021 - 06/2006
3	Stomach Neoplasms (Stomach Cancer) 12/2021 - 01/2019
3	Atherosclerosis 01/2021 - 03/2011
3	Carcinogenesis 01/2020 - 08/2013
3	Infections 07/2012 - 09/2005
3	Pneumonia (Pneumonitis) 01/2011 - 09/2007
2	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 11/2016
2	Inflammation (Inflammations) 01/2022 - 01/2020
2	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2021 - 01/2012
2	Neoplasm Metastasis (Metastasis) 01/2021 - 05/2014
2	Demyelinating Diseases (Demyelinating Disease) 07/2020 - 07/2016
2	Tauopathies 11/2017 - 11/2016
2	Spinal Cord Injuries (Spinal Cord Injury) 07/2016 - 01/2013
2	Multiple Sclerosis 07/2016 - 05/2014
2	Body Weight (Weight, Body) 11/2015 - 02/2014
2	Chronic Renal Insufficiency 04/2014 - 08/2013
2	Liver Failure 04/2014 - 08/2013
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 02/2014 - 08/2009
2	Type 2 Diabetes Mellitus (MODY) 09/2013 - 09/2004
2	Seasonal Allergic Rhinitis (Hay Fever) 03/2011 - 10/2009
2	Lymphoma (Lymphomas) 03/2008 - 05/2004
1	Cognitive Dysfunction 10/2022
1	Hernia (Hernias) 03/2022
1	Rectal Neoplasms (Rectal Cancer) 03/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Heart Failure 01/2022
1	Memory Disorders (Memory Loss) 10/2021
1	Pathologic Constriction (Stenosis) 01/2021
1	Atherosclerotic Plaque (Atheroma) 01/2021
1	Hyperplasia 01/2021
1	Neuroinflammatory Diseases 07/2020
1	Dehydration (Water Stress) 05/2019
1	Colorectal Neoplasms (Colorectal Cancer) 05/2019
1	Lymphatic Metastasis 05/2019
1	Shock 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2017
1	Substance-Related Disorders (Drug Abuse) 11/2016
1	Amyloid Plaque 06/2016
1	Temporal Lobe Epilepsy 12/2015
1	Seizures (Absence Seizure) 12/2015
1	Epilepsy (Aura) 12/2015

Drug/Important Bio-Agent (IBA)

10	Heparitin Sulfate (Heparan Sulfate)IBA 06/2016 - 04/2002
9	Chondroitin Sulfates (Chondroitin Sulfate)IBA 01/2022 - 09/2005
8	GlycosaminoglycansIBA 01/2022 - 10/2003
8	ChondroitinIBA 10/2021 - 05/2003
5	GlycosyltransferasesIBA 07/2020 - 04/2002
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 10/2003
4	EnzymesIBA 10/2022 - 12/2006
4	Biological ProductsIBA 01/2022 - 11/2017
4	DNA (Deoxyribonucleic Acid)IBA 05/2019 - 04/2010
4	Pharmaceutical PreparationsIBA 09/2013 - 06/2006
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 01/2019
3	Proteoglycans (Proteoglycan)IBA 01/2021 - 03/2011
3	CytokinesIBA 01/2020 - 07/2009
3	Chondroitin Sulfate ProteoglycansIBA 11/2017 - 07/2016
3	Polychlorinated Dibenzodioxins (TCDD)IBA 11/2015 - 08/2009
2	Matrix Metalloproteinases (MMPs)IBA 12/2021 - 01/2021
2	LDL Receptors (LDL Receptor)IBA 01/2021 - 03/2011
2	Phosphotransferases (Kinase)IBA 01/2021 - 03/2013
2	Cadherins (E-Cadherin)IBA 01/2021 - 12/2018
2	chondroitin sulfate N-acetylgalactosaminyltransferase-2IBA 01/2021 - 01/2019
2	CateninsIBA 01/2021 - 12/2018
2	oxidized low density lipoproteinIBA 01/2019 - 03/2011
2	LDL Lipoproteins (beta Lipoproteins)IBA 01/2019 - 03/2011
2	Lipoproteins (Lipoprotein)IBA 01/2019 - 03/2011
2	Messenger RNA (mRNA)IBA 11/2017 - 07/2009
2	Carbon Tetrachloride (Tetrachloromethane)IBA 04/2014 - 08/2013
2	Phosphates (Orthophosphate)IBA 04/2014 - 08/2013
2	Metformin (Glucophage)FDA LinkGeneric 09/2013 - 08/2013
2	Insulin (Novolin)FDA Link 08/2013 - 09/2004
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2012 - 06/2006
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2011 - 09/2007
2	Heparin (Liquaemin)FDA LinkGeneric 10/2003 - 07/2002
1	Memantine (Namenda)FDA Link 10/2022
1	Imiquimod (Aldara)FDA LinkGeneric 01/2021
1	Syndecan-1 (Syndecan 1)IBA 01/2021
1	Farnesyltranstransferase (Farnesyltransferase)IBA 01/2021
1	chondroitin sulfate glycosaminoglycanIBA 01/2021
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 01/2021
1	tipifarnib (R115777)IBA 01/2021
1	Hyaluronic Acid (Hyaluronan)IBA 01/2021
1	Metal-Organic FrameworksIBA 05/2019
1	Protons (Proton)IBA 05/2019
1	OxalatesIBA 05/2019
1	ImmunosorbentsIBA 05/2019
1	IceIBA 01/2019
1	Cathepsin DIBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	SilicatesIBA 01/2019
1	SuspensionsIBA 11/2017
1	AntibodiesIBA 11/2017
1	Amyloid (Amyloid Fibrils)IBA 06/2016

Therapy/Procedure

5	Therapeutics 01/2021 - 06/2006
2	Nephrectomy 04/2014 - 08/2013
2	Immunotherapy 03/2011 - 10/2009
1	Proctectomy 03/2022
1	Complementary Therapies (Alternative Medicine) 03/2015